Table 3.
Local cutaneous reaction to LC16mO, LC16m8, and conventional vaccinia vaccines (1968–1974)
| Vaccine strain | Year of investigation | No. of persons examined | % Successful vaccinationa | Mean erythema diametera (mm) | Average induration diametera (mm) | Febrile reactionb (%) |
|---|---|---|---|---|---|---|
| Ikeda | 1968–1970 | 1506 | 99.1 | 22.9 | 18.2 | 25.0 |
| Ecuador | 1969–1970 | 1846 | 67.5 | 19.2 | 17.4 | 21.3 |
| Lister | 1968–1971 | 3662 | 93.7 | 17.6 | 15.3 | 26.6 |
| CVI-78 (Japan) | 1971–1973 | 22976 | 92.4 | 21.1 | 16.8 | 8.5 |
| LC16mO | 1973–1974 | 829 | 94.8 | 19.6 | 14.5 | 12.1 |
| LC16m8 | 1973–1974 | 10578 | 95.1 | 18.4 | 6.1 | 7.7 |
Source: Yamaguchi et al. [4].
a
Take rate, aggregated by highest ratio of successful vaccination or at the time of largest diameter.
b
Aggregated febrile cases from Days 4 to 14.