Table 5.
Antibody response to LC16m8 and conventional smallpox vaccines
| Strain | Time post-vaccination (in months) | Cases observed | HI antigenic value |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| <2–4 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | Average | |||
| LC16m8 | 1–1.5 | 513 | 18 | 12 | 88 | 161 | 155 | 72 | 6 | 1 | 23.3 |
| 3–6 | 19 | 1 | 3 | 3 | 3a | 3a | 6 | 23.2 | |||
| LC16mO | 1–1.5 | 47 | 4 | 23 | 16 | 4 | 24.4 | ||||
| CVI-78 | 1–1.5 | 26 | 1 | 7 | 11 | 7 | 23.0 | ||||
| 3–6 | 25 | 2 | 10 | 11 | 1 | 1 | 23.6 | ||||
| Lister | 1–1.5 | 7 | 5 | 2 | 24.3 | ||||||
| 3–6 | 19 | 4 | 5 | 8 | 2 | 23.4 | |||||
| Strain | Monthly progress | Cases observed | PRNT antigenic value |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| <40.9 | 41.0 | 41.5 | 42.0 | 42.5 | 43.0 | 43.5 | 44.0 | Average | |||
| LC16m8 | 1–1.5 | 97 | 5 | 10 | 25 | 37 | 18 | 2 | 42.5 | ||
| LC16mO | 1–1.5 | 15 | 6 | 9 | 43.0 | ||||||
| CVI-78 | 1–1.5 | 6 | 1 | 2 | 2 | 1 | 41.9 | ||||
| 3–6 | 11 | 1 | 1 | 4 | 2 | 3 | 42.0 | ||||
| Lister | 1–1.5 | 5 | 3 | 2 | 42.4 | ||||||
| 3–6 | 12 | 1 | 2 | 2 | 7 | 42.2 | |||||
Note: PRNT titers were done on four-fold dilutions of the test sera.
Error in original Japanese source [4] shows 2.