Table 1.
Reduction of viral titer, inhibition of cytopathic effect and antiviral activity against HHV-1, HHV-2 and DENV-2 of ferruginol analogues 8 and 9.
| Vero cell linea | ||||||
|---|---|---|---|---|---|---|
| Compound | HHV-1 |
HHV-2 |
DENV-2 |
|||
| Rfb | Antiviral activity (μM)c | Rfb | Antiviral activity (μM)c | CPE inhibitiond | Antiviral activity (μM)c | |
| 8 | 102 | 14.5 | 103 | 29.0 | + | 29.0 |
| 9 | NA | NA | 103 | 41.7 | + | 41.7 |
| ACV | 104 | 6.7 | 103 | 6.7 | NT | NT |
| RIBA | NT | NT | NT | NT | + | 123.0 |
HHV-1: Human Herpesvirus type 1 (CDC Atlanta strain). HHV-2: Human Herpesvirus type 2 (VR-734-G strain). DENV-2: Dengue virus (New Guinea strain). NT: not tested. NA: not active.
These values represent the mean of two independent experiments.
a
Vero Cercopithecus aethiops African green monkey kidney cell line ATCC CCL-81.
b
Reduction factor of the viral titer.
c
Maximal non-toxic concentration that showed viral reduction factor.
d
Cytopathic effect inhibition (+).