Table 2.
Cytotoxicity (IC50-μM) of ferruginol (1) and analogues 5–14 on HeLa, Jurkat, U937 and Vero cell lines.
| Compound | Cell linesc |
||||||
|---|---|---|---|---|---|---|---|
| HeLa |
Jurkat |
U937 |
Vero |
||||
| IC50a (μM) | SIb | IC50a (μM) | SIb | IC50a (μM) | SIb | IC50a (μM) | |
| 1 | 64.9 | 1.4 | 48.2 | 1.9 | 21.3 | 4.2 | 90.4 |
| 5 | >50 | NA | >50 | NA | >50 | NA | NE |
| 6 | >80 | NA | 49.4 | 0.8 | >80 | NA | 39.8 |
| 7 | >50 | NA | 30.9 | 2.7 | 36.0 | 2.3 | 82.5 |
| 8 | >50 | NA | >50 | NA | >50 | NA | NE |
| 9 | 60.0 | 1.5 | 21.6 | 4.2 | 33.2 | 2.7 | 90.8 |
| 10 | 29.0 | 9.2 | 21.9 | 12.2 | >40 | NA | 266.8 |
| 11 | >40 | NA | >40 | NA | >40 | NA | NE |
| 12 | 7.3 | >43.8 | 12.3 | >26.0 | 8.3 | >38.5 | >320 |
| 13 | >30 | NA | >30 | NA | >30 | NA | NE |
| 14 | >30 | NA | >30 | NA | >30 | NA | NE |
| PXT | 0.099 | NA | 0.0005 | NA | 0.006 | NA | 0.65 |
| DOX | 0.834 | NA | 0.012 | NA | 0.077 | NA | 1.93 |
PXT: Paclitaxel; DOX: Doxorubicine. NA: Not apply; NE: Not evaluated. These values represent the geometric mean of two independent experiments, each one made by quadruplicate.
a
Inhibitory concentration 50 defined as concentration of compounds that induces 50% of growth inhibition at 48 h.
b
SI, selectivity index defined as VERO IC50 over either Jurkat, U937 or HeLa IC50.
c
Jurkat, human acute T cell leukemia ATCC TIB-152; U937, human promonocytic cell line ATCC CRL-1593.2; HeLa, human cervix epitheloid adenocarcinoma cells ATCC CRL-1958; Vero, Cercopithecus aethiops African green monkey kidney cells ATCC CCL-81.