Table 1.

Cytotoxic activity of compounds 3–17 against murine leukemia cells (L1210/0), and human T-lymphocyte cells (Molt 4/C8 and CEM/0), and theoretically calculated Clog P values.

Compound	IC50 (μM)			Clog P
	L1210/0	Molt 4/C8	CEM/0
Cytarabine	0.024 ± 0.009	–	0.024 ± 0.001	−1.57
3	>500	>500	>500	−0.62
4	312 ± 4	380 ± 30	254 ± 3	−0.60
5	211 ± 6	299 ± 61	217 ± 13	−3.81
6	>500	>500	>500	−2.13
7	>500	>500	>500	−0.07
8	>500	>500	>500	−1.61
9	254 ± 32	226 ± 13	215 ± 15	5.19
10	6.0 ± 0.1	7.9 ± 1.3	7.5 ± 0.1	5.13
11	30 ± 5	18 ± 11	17 ± 5	1.91
12	201 ± 21	129 ± 80	126 ± 67	5.66
13	229 ± 17	185 ± 42	212 ± 12	5.91
14	>500	>500	>500	−0.07
15	>500	>500	>500	−1.60
16	>500	>500	>500	0.18
17	>500	>500	>500	−1.60