Table 2.
Anticonvulsant screening project (ASP): Phase 1- test results in mice
| Test 1 results – Intraperitoneal injection in mice |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Compd. | MES screening |
scPTZ screening |
Minimal motor impairment screening |
|||||||||||||||
| 30 mg/kg |
100 mg/kg |
300 mg/kg |
30 mg/kg |
100 mg/kg |
300 mg/kg |
30 mg/kg |
100 mg/kg |
300 mg/kg |
||||||||||
| 0.5 h (N/F) | 4.0 h (N/F) | 0.5 h (N/F) | 4.0 h (N/F) | 0.5 h (N/F) | 4.0 h (N/F) | 0.5 h (N/F) | 4.0 h (N/F) | 0.5 h (N/F) | 4.0 h (N/F) | 0.5 h (N/F) | 4.0 h (N/F) | 0.5 h (N/F) | 4.0 h (N/F) | 0.5 h (N/F) | 4.0 h (N/F) | 0.5 h (N/F) | 4.0 h (N/F) | |
| 5a | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5b | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5c | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5d | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5e | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5f | 0/1 | 0/1 | 0/3 | 0/3 | 1/1 | 1/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5g | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5h | 0/1 | 0/1 | 0/3 | 0/3 | 1/1 | 1/1 | 0/1 | 0/1 | 0/1 | 0/1 | 1/5 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5i | 0/1 | 0/1 | 0/3 | 1/3 | 1/1 | 1/1 | 0/1 | 0/1 | 0/1 | 0/1 | 2/5 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5j | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5k | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 1/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 1/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5l | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 1/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 1/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5m | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5n | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5o | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
| 5p | 0/1 | 0/1 | 0/3 | 0/3 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0/4 | 0/2 | 0/8 | 0/4 | 0/4 | 0/2 |
N/F = Number of animals active or toxic over the number tested.