Table 1.
Activity and nasal discharge in ferrets challenged with SARS-CoV
| Mean activity scorea |
Nasal discharge (%)b |
||||||
|---|---|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 1 | Day 2 | |
| AdHu5-LacZ | 0 | 0.8 | 1 | 1 | 1 | 66.7 | 33.3 |
| AdHu5-nSpike | 0 | 0.2 | 1 | 1 | 0 | 33.3 | 16.7 |
| AdC7-nSpike | 0 | 1 | 0.7 | 0.7 | 0 | 66.7 | 16.7 |
| AdHu5-/AdC7-nSpike | 0 | 1.2 | 0.2 | 0 | 0 | 16.7 | 16.7 |
a
Mean activity score represent the group average of daily activity scores for each ferret (score: 0, normal; 1, alert but playful only when stimulated; 2, alert but not playful when stimulated; 3, neither alert nor playful when stimulated; the scoring system is based on that described by Reuman et al. [30].
b
Percent of ferrets per group with serous nasal discharge. Note that nasal discharge was mainly resolved by day 3. Six ferrets per group were evaluated at days 1, 2 and 3 ferrets per group at days 3–5.