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. 2019 Jan 30;166:328–338. doi: 10.1016/j.ejmech.2019.01.074

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© 2019 Elsevier Masson SAS. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Scheme 4 — Reagents and conditions: (a) benzyl bromide, K₂CO₃, DMF, 50 °C, 80%; (b) NaH, propargyl bromide, THF, 65 °C, 60%; (c) sodium l-ascorbate, 6^A-azide-6^A-deoxy-per-O-acetylated-β-CD (16), CuSO₄, THF-H₂O (1:1, v/v), 60%; (d) Pt/C, H₂, CH₃OH, 76%; (e) CH₃ONa/CH₃OH, 81%.