Fig. 5.

Protection of mice from homologous and heterologous virus challenge. Three weeks after the boost vaccination, the immunized mice were arbitrarily divided into three groups (n = 6) and challenged with H7N9-53, H7N9-MCX and H7N9-ZSM, respectively (100 × MLD₅₀). Weight loss (left panel) and survival rates (right panel) of immunized mice challenged with homologous H7N9-53 virus (Yangtze River Delta) (A, B). Heterologous H7N9-MCX virus (Yangtze River Delta) (C, D). Heterologous H7N9-ZSM virus (Pearl River Delta) (E, F) were monitored for 14 days.