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Inhibitory activity of soluble epoxide hydrolase and interaction for ester N2, N3, N4 and N5.
| Com. | Inhibitory activity |
Interaction and Autodock score |
|||
|---|---|---|---|---|---|
| 100 μM (%) | IC50 (μM) | Type | Hydrogen bonds (Å) | Binding energyb | |
| N2 | >100 | 9.1 | a | Tyr343(2.68), Gln384(2.79), Asn378(2.62), Met503(3.22) | −7.36 |
| N3 | >100 | 18.0 | a | Thr360(2.71), Gln384(3.06) | −6.79 |
| N4 | 97.4 | 27.2 | a | Gln384(2.91) | −8.27 |
| N5 | >100 | 6.4 | a | Asp335(3.30), Gln384(3.14) | −7.87 |
| AUDAc | 4.4 | ||||
a: competitive; b: kcal/mol; c: positive control.
