TABLE 1.
DC-SIGN allelic frequencies of the seven htSNPs in healthy individuals and leprosy patients
SNP | N | Frequency | Cases versus Controls |
BT + TT versus BL + LLa |
|||
---|---|---|---|---|---|---|---|
OR | p | OR | p | ||||
−939G | Controls | 78 | 0.577 | ||||
Cases | 194 | 0.606 | 1.13 | 0.55 | |||
BT + TT | 85 | 0.582 | 0.93 | 0.92 | 0.84 | 0.41 | |
BL + LL | 109 | 0.624 | 1.22 | 0.36 | |||
−871A | Controls | 78 | 0.712 | ||||
Cases | 194 | 0.745 | 1.18 | 0.43 | |||
BT + TT | 85 | 0.724 | 1.06 | 0.81 | 0.72 | 0.40 | |
BL + LL | 109 | 0.761 | 1.29 | 0.28 | |||
−336A | Controls | 78 | 0.859 | ||||
Cases | 194 | 0.819 | 0.74 | 0.26 | |||
BT + TT | 85 | 0.839 | 0.86 | 0.62 | 1.28 | 0.36 | |
BL + LL | 109 | 0.803 | 0.67 | 0.16 | |||
−139G | Controls | 78 | 0.564 | ||||
Cases | 194 | 0.567 | 1.01 | 0.95 | |||
BT + TT | 85 | 0.565 | 1.00 | 0.99 | 0.98 | 0.94 | |
BL + LL | 109 | 0.569 | 1.02 | 0.93 | |||
2392G | Controls | 78 | 0.974 | ||||
Cases | 194 | 0.982 | 1.43 | 0.57 | |||
BT + TT | 85 | 0.976 | 1.09 | 0.90 | 0.58 | 0.47 | |
BL + LL | 109 | 0.986 | 1.89 | 0.40 | |||
3838A | Controls | 78 | 0.949 | ||||
Cases | 194 | 0.936 | 0.78 | 0.56 | |||
BT + TT | 85 | 0.935 | 0.78 | 0.61 | 0.99 | 0.99 | |
BL + LL | 109 | 0.936 | 0.79 | 0.60 | |||
4235G | Controls | 78 | 0.917 | ||||
Cases | 194 | 0.894 | 0.77 | 0.43 | |||
BT + TT | 85 | 0.918 | 1.01 | 0.97 | 1.58 | 0.19 | |
BL + LL | 109 | 0.876 | 0.64 | 0.21 |
Given the absence of significant differences between LL versus BL and TT versus BT (results not shown), individuals were grouped into lepromatous patients (BL + LL; n = 109) and tuberculoid patients (BT + TT; n = 85).