Table 5.

Human versus human proteome overlap at the 5-mer level

Human sub-proteomea	1	2	3b	4b	5	6
1	1,566	1,567	1,496	27,014	14,381	95.5
2	1,598	1,600	1,576	26,352	13,850	98.6
3	1,937	1,956	1,885	44,087	17,222	97.3
4	2,100	2,106	2,064	30,025	14,400	98.2
5	2,058	2,162	1,986	40,374	17,653	96.5
6	2,131	2,262	2,098	62,564	16,698	98.4
7	2,289	2,417	2,227	37,796	17,303	97.2
8	2,556	2,557	2,475	33,387	16,439	96.8
9	2,858	2,931	2,721	81,650	20,105	95.2
10	3,067	3,120	3,042	48,918	19,069	99.1
11	3,306	3,351	3,198	59,666	21,568	96.7
12	3,355	3,383	3,271	68,549	22,697	97.4
13	3,478	3,510	3,377	56,469	21,221	97.0
14	3,529	3,554	3,417	60,138	21,490	96.8
15	3,663	3,673	3,596	88,229	22,454	98.1
16	3,626	3,715	3,545	96,827	22,061	97.7
17	4,084	4,095	3,958	72,451	23,645	96.9
18	4,374	4,385	4,112	68,579	24,055	94.0
19	4,423	4,476	4,295	79,283	24,472	97.1
20	4,751	4,795	4,735	70,296	22,686	99.6
21	4,646	4,768	4,555	115,916	26,284	98.0
22	4,886	4,901	4,850	95,959	25,348	99.2
23	5,048	5,168	4,740	72,400	23,453	93.8
24	5,408	5,428	5,144	101,686	26,713	95.1
25	5,941	5,977	5,841	128,904	27,751	98.3
26	13,143	14,063	12,700	290,022	32,681	96.6
27	33,281	34,606	32,460	664,539	35,181	97.5
28	42,683	44,263	41,535	787,778	35,375	97.3
29	51,865	53,804	50,075	895,672	35,489	96.5
30	62,219	65,156	60,506	1,103,962	35,629	97.2
Allc	254,808	299,749	246,322	3,713,010

All 30 artificial human sub-proteomes constitute 686 proteins and are numbered from 1 to 30. The comparison human proteome contained 36,103 proteins and 15,771,565 occurrences of 2,388,563 unique 5-mers. Column number refers to: (1) unique 5-mers in the artificial sub-proteome; (2) total number of 5-mers in the artificial sub-proteome (including multiple occurrences); (3) unique 5-mers from the artificial sub-proteome occurring in the human proteome; (4) occurrences in the human proteome of 5-mers from artificial sub-proteome (including multiple occurrences); (5) number of human proteins in the human proteome involved in overlap; (6) % of unique 5-mers from the artificial sub-proteome which occur in the human proteome (i.e. 100 × column 3/column 1).

^aAnalogous to viral proteomes in size (see Table 1), and composed by set of human proteins as detailed in Table 3.

^bThe results of linear regression analysis between columns 1 and 3, and 1 and 4 are: column 3 = 0.97083 × column 1 + 0.76628 (r = 0.99998). Column 4 = 17.921 × column 1 + 6278.6 (r = 0.99719).

^cObtained by combining all 30 human sub-proteomes into one sub-proteome, and then computing the overlap with the entire original human proteome minus the proteins in the combined sub-proteomes.