Table 2.
Anti-Feline Corona Virus (FIPV) and anti-Feline Herpes Virus activity and cytotoxicity in Crandell-Rees Feline Kidney (CRFK) cell cultures.
| Compound | CC50 (μM)a | EC50 (μM)b |
|
|---|---|---|---|
| Feline corona virus (FIPV) | Feline herpes virus | ||
| 5a | 25.1 | 1.1 | >20 |
| 5b | 50.6 | >20 | >20 |
| 5c | >100 | 9.0 | >100 |
| 5d | >100 | >100 | >100 |
| 5e | >100 | >100 | >100 |
| 5f | >100 | >100 | >100 |
| 5g | >100 | >100 | >100 |
| HHA (μg/ml) | >100 | 32.5 | 2.9 |
| UDA (μg/ml) | 63.2 | 1.6 | 1.0 |
| Ganciclovir | >100 | >100 | 4.1 |
a
50% Cytotoxic concentration as determined by measuring the cell viability with the colorimetric formazon-based MTS assay.
b
50% Effective concentration or concentration producing 50% inhibition of virus-induced cytopathic effect as determined by measuring the cell viability with the colorimetric formazon-based MTS assay.