Table 1.
Immunization of African green monkeys with b/h PIV3/hMPV F2 protects against wt hMPV/NL/1/00 challenge
| Immunizinga virus | No. of animals | Mean peak titersb log10 pfu/ml |
|||
|---|---|---|---|---|---|
| Pre-challenge |
Post-challengec |
||||
| NP | BAL | NP | BAL | ||
| hMPV/NL/1/00 | 4 | 4.4 ± 0.4 | 5.4 ± 0.4 | <1.3 ± 0.0 | <1.3 ± 0.0 |
| b/hPIV3/hMPV F2 | 4 | 6.0 ± 0.1 | 6.0 ± 0.5 | 2.3 ± 1.1 | <1.3 ± 0.0 |
| Placebo | 4 | <1.3 ± 0.0 | <1.3 ± 0.0 | 4.7 ± 0.4 | 5.6 ± 0.6 |
a
Animals were inoculated intranasally and intratracheally with 3–4 × 105 pfu of the indicated virus at each site.
b
Mean of the highest titers obtained for each group of animals expressed as log10 pfu/ml ± standard deviation.
c
Animals were challenged on day 28 with 5 × 105 pfu of hMPV/NL/1/00.