Table 3.
Immunization of African green monkeys with b/h PIV3/hMPV F2 elicits hPIV3 neutralizing and HAI serum antibodies
| Virus immunized | Day of sera collection | hPIV3 neutralizing antibody titer reciprocal log2 ± S.D. | Mean reciprocal log2 ± S.D. PIV3 HAI antibody titers |
|
|---|---|---|---|---|
| hPIV3a | bPIV3a | |||
| b/h PIV3/hMPV F2 | 1 | <2 | <2 | <2 |
| 28 | 7.2 ± 1.3 | 10.5 ± 0.6 | 8.5 ± 1.3 | |
| 56 | 7.2 ± 0.5 | 10.0 ± 1.2 | 7.3 ± 1.0 | |
| Placebo | 1 | <2b | ND | ND |
| 28 | <2b | ND | ND | |
| 56 | <2b | <2b | <2b | |
a
hPIV3/Wash/47885/57 and bPIV3/Kansas/15626/84 served as antigens in the HAI assay.
b
One of the four placebo animals was positive for hPIV3 at pre-screening (day −21). The positive animal is not included in the mean.