Table 14.
Cytotoxicity and antiviral activity of synthesized benzimidazole derivatives in in Vero cell cultures.
| Comp. | Minimum cytotoxic concentrationa (μg/ml) | EC50b (μg/ml) |
||||
|---|---|---|---|---|---|---|
| Para-influenza-3 virus | Reovirus-1 | Sindbis virus | Coxsackie virus B4 | Punta Toro virus | ||
| 1 | 20 | >4 | >4 | >4 | >4 | >4 |
| 2 | >100 | >100 | >100 | >100 | >100 | >100 |
| 3 | >100 | >100 | >100 | >100 | >100 | >100 |
| 4 | >100 | >100 | >100 | >100 | >100 | >100 |
| 5 | >100 | >100 | >100 | >100 | >100 | >100 |
| 6 | >100 | >100 | >100 | >100 | >100 | >100 |
| 7 | >100 | >100 | >100 | >100 | >100 | >100 |
| 8 | >100 | >100 | >100 | >100 | >100 | >100 |
| 9 | >100 | >100 | >100 | >100 | >100 | >100 |
| 10 | >100 | >100 | >100 | >100 | >100 | >100 |
| 11 | >100 | >100 | >100 | >100 | >100 | >100 |
| 12 | >100 | >100 | >100 | >100 | >100 | >100 |
| 13 | >100 | >100 | >100 | >100 | >100 | >100 |
| 14 | >100 | >100 | >100 | >100 | >100 | >100 |
| 15 | >100 | >100 | >100 | >100 | >100 | >100 |
| 16 | >100 | >100 | >100 | >100 | >100 | >100 |
| 17 | >100 | >100 | >100 | >100 | >100 | >100 |
| 18 | >100 | >100 | >100 | >100 | >100 | >100 |
| 19 | >100 | >100 | >100 | >100 | >100 | >100 |
| 20 | >100 | >100 | >100 | >100 | >100 | >100 |
| DS-5000 | >100 | >100 | >100 | 100 | 58 | 100 |
| (S)-DHPA (μM) | >250 | >250 | >250 | >250 | >250 | >250 |
| Ribavirin (μM) | >250 | 95 | 112 | >250 | 250 | 112 |
a
Required to cause a microscopically detectable alteration of normal cell morphology.
b
Required to reduce virus-induced cytopathogenicity by 50%.