Table 10.

Result of anti-inflammatory activity of the tested derivatives.

Com.	IC50 (μM)		Selectivity index (SI)	Anti-inflammatory activity (% inhibition)
	COX-1	COX-2
119	–	–	–	61.23
120	–	–	–	61.02
121	–	–	–	61.84
122	–	–	–	62.00
123	–	–	–	62.51
124	–	–	–	62.05
125	2.86	0.39	7.36	62.30
126	–	–	–	77.88
127	–	–	–	79.91
128	–	–	–	56.2
129	–	–	–	55.2
130	80	0.20	400	91.00
131	>100	1.00	>100	92.00
132	13.40 × 10−5	2.83 × 10−5	4.73	56.00
133	22.72 × 10−5	4.69 × 10−5	4.84	61.00
134	1.60		0.98	80.00
135	1.57		0.91	98.00
136	1.74		0.99	89.20
137	4.08	0.77	5.29	–
138	3.81	0.72	5.29	72.72
139	3.76	0.66	5.69	–
140	–	–	–	72.72