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. 2019 Nov 16;186:111893. doi: 10.1016/j.ejmech.2019.111893

Table 7.

Bioactivity of compounds 97 and 98.

Com. Ki (nM) MAO-A Ki (nM) MAO-B SIa MAO-A IC50 (nM) MAO-B IC50 (nM) ED50 (μM) in vivo
Deprenyl – – – 3.90 × 10−6 3.00 × 10−8 0.30
97 0.014 121.34 8667.143 2.34 × 10−6 13.23 × 10−8 19.23
98 0.346 765.87 2213.497 7.99 × 10−6 45.43 × 10−8 47.54
a

SI (selectivity index) = Ki (MAO-B)/Ki (MAO-A) ratio.