Table 2.
Neonatal Medical Data
| N (%) of Mean (SD) | Profile 6 N=46 | Profiles 1–5 N=615 | Unadjusted β or Odds Ratio (95%CI) | Adjusted β or Odds Ratio (95%CI) |
|---|---|---|---|---|
| Birth GA <27 weeks | 23 (50.0) | 267 (43.4) | 1.30 (0.72, 2.37) | 1.24 (0.68, 2.27) |
| Birth HC (cm) | 23.6 (2.3) | 24.6 (2.4) | −1.00 (−1.72, −0.27) | −0.87 (−1.59, −0.14) |
| Length of NICU stay (days) | 103 (45) | 92 (42) | 11.00 (−1.71, 23.70) | 11.24 (−1.55, 24.03) |
| Discharge weight (g) | 3036 (846) | 3000 (891) | 36 (−233, 305) | 118 (−148, 384) |
| Post menstrual age (wks) at discharge | 41.6 (5.1) | 40.3 (5.1) | 1.32 (−0.22, 2.87) | 1.38 (−0.18, 2.93) |
| Chronic Lung Diseasea | 21 (45.7) | 314 (51.1) | 0.81 (0.44, 1.47) | 0.82 (0.45, 1.51) |
| Necrotizing enterocolitis (NEC)b | 4 (8.7) | 39 (6.3) | 1.41 (0.48, 4.12) | * |
| Bacterial Sepsis (<= day 3) | 4 (8.7) | 15 (2.4) | 3.80 (1.21, 11.97) | * |
| Bacterial Sepsis (> day 3) | 13 (28.3) | 56 (9.1) | 3.93 (1.96, 7.90) | 3.39 (1.66, 6.92) |
| Severe ROP c | 1 (2.2) | 39 (6.3) | 0.33 (0.04, 2.45) | * |
| Germinal Matrix Hemorrhage (GMH) | 9 (19.6) | 138 (22.4) | 0.84 (0.40, 1.79) | 0.85 (0.40, 1.82) |
| GMH Early | 9 (20.0) | 113 (18.5) | 1.10 (0.52, 2.35) | 1.16 (0.54, 2.48) |
| GMH Late | 4 (8.7) | 62 (10.7) | 0.80 (0.28, 2.30) | * |
| Any Intraventricular Hemorrhage (IVH) | 10 (21.7) | 107 (17.4) | 1.32 (0.64, 2.74) | 1.31 (0.63, 2.73) |
| IVH Early | 8 (17.8) | 98 (16.1) | 1.13 (0.51, 2.50) | 1.17 (0.53, 2.61) |
| IVH Late | 9 (19.6) | 58 (10.0) | 2.19 (1.01, 4.77) | 1.98 (0.90, 4.36) |
| Ventricular Dilation | 4 (8.7) | 46 (7.5) | 1.18 (0.41, 3.43) | * |
| Ventricular Dilation Early | 4 (9.5) | 33 (5.5) | 1.80 (0.61, 5.35) | * |
| Ventricular Dilation Late | 4 (8.7) | 35 (6.1) | 1.46 (0.50, 4.32) | * |
| Parenchymal echolucency (PVL) | 6 (13.0) | 37 (6.0) | 2.34 (0.93, 5.88) | 2.27 (0.89, 5.75) |
| Parenchymal echodensity | 6 (13.0) | 46 (7.5) | 1.86 (0.75, 4.61) | 1.82 (0.73, 4.56) |
a
oxygen requirement at 36 weeks PMA
b
Bell’s classification ≥ stage 2
c
Stage 4 or 5 or requiring surgery
*
Categorical medical outcomes were adjusted for study site if there was sufficient cell size (≥5 per group) and statistically significant associations with NNNS profiles (p<.05).
Notes: For continuous medical data, data are unstandardized coefficients from linear regression analysis; for categorical medical data, data are odds ratios from logistic regression analyses