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Causas de agudización de la EPOC
| Virus | Rinovirus (resfriado común) |
| Parainfluenza | |
| Influenza | |
| Coronavirus | |
| Adenovirus | |
| Virus respiratorio sincitial | |
| Bacterias | Haemophilus influenzae |
| Streptococcus pneumoniae | |
| Moraxella catarrhalis | |
| Pseudomonas aeruginosa | |
| Organismos atípicos | Chlamydophila pneumoniae |
| Mycoplasma pneumoniae | |
| Polución ambiental | Ozono |
| Partículas ≤ 10 μm de diámetro | |
| Dióxido de sulfuro | |
| Dióxido de nitrógeno |
