Table 4. The Mutation-Adjusted Risk Score (MARS) for advanced SM.
| Criterion | Points |
|---|---|
| Age >60 years | 1 |
| Platelets <100 × 109/L | 1 |
| Hemoglobin <10 g/dL | 1 |
| S/A/R panel positive (1 gene)a | 1 |
| S/A/R panel positive (≥2 genes)b | 2 |
The MARS delineates 3 categories of risk for advanced SM: low risk (median overall survival (OS) not reached): 0 to 1 point; intermediate risk (median OS, 3.9 years): 2 points; and high risk (median OS, 1.9 years): 3 to 5 points.
a
Presence of one molecular high risk gene mutation (i.e. in SRSF2, ASXL1, and/or RUNX1; S/A/R gene panel), or
b
presence of two or more molecular high risk gene mutations in the S/A/R gene panel.