Table 4. Multivariate analysis of the influence of selected parameters on event-free survival (EFS) and overall survival (OS).
| Multivariate analysis of the influence of selected parameters on EFS |
Multivariate analysis of the influence of selected parameters on OS |
|||
|---|---|---|---|---|
| Variable | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age (y) | 1.06 (1.04; 1.09) | <.001 | 1.11 (1.08; 1.14)a | <.001 |
| Serum tryptase (ng/mL) | 1.00 (1.00; 1.00) a | .093 | 1.00 (1.00; 1.00)a | .253 |
| Platelets (×103/μL) | 1.00 (0.99; 1.00) a | .485 | 1.00 (1.00; 1.00)a | .943 |
| Gender (female vs male) | 0.50 (0.28; 0.86) | .013 | 0.54 (0.27; 1.05) | .070 |
| Performance status: symptoms/need to be in bed (vs normal activity) | 2.11 (1.19; 3.72) | .010 | 2.02 (1.05; 3.91) | .036 |
| Spleen (palpable) (yes vs no) | 1.37 (0.55; 3.41) | .492 | 3.39 (1.15; 10.03) | .027 |
| Hepatomegaly (palpable) (yes vs no) | 1.99 (0.86; 4.60) | .106 | 1.36 (0.48; 3.85) | .563 |
| Lymphadenopathy (yes vs no) | 4.96 (1.76; 13.96) | .002 | 0.54 (0.27; 1.05) | .070 |
Note: Results of Cox regression multivariate analysis of the influence of selected parameters on PFS and OS in indolent systemic mastocytosis (ISM), bone marrow mastocytosis (BMM), smoldering systemic mastocytosis (SMM) and cutaneous mastocytosis (CM). Statistically significant parameters (P < .05) from univariate Cox analyses were put into multivariate Cox analysis. Performance status is binarized: symptoms/need to be in bed vs normal activity. N = 1043.
Abbreviations: HR, hazard ratio; CI, confidence interval.
a
Elevated vs normal.
Bold P-values are statisticly significant.