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. Author manuscript; available in PMC: 2020 Jul 30.
Published in final edited form as: Biochemistry. 2019 Nov 8;59(1):12–14. doi: 10.1021/acs.biochem.9b00893

Figure 1. Crystal structure of Cmp2105-bound chemokine receptor CCR7.

Figure 1

(A) Overall representation of the Cmp2105–CCR7 crystal structure based on Protein Data Bank entry 6QZH. Cmp2105 is colored red. H8 is helix 8. ECL2 is extracellular loop 2. (B) Chemical structure of Cmp2105 generated using Marvin JS version 18.27.0. (C) Structural view of the receptor from the cytoplasmic side to highlight the binding pocket of Cmp2105 on CCR7. Cmp2105 is colored red, and CCR7 helices are labeled for the sake of clarity.