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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Nat Rev Neurosci. 2020 Feb 10;21(3):153–168. doi: 10.1038/s41583-019-0260-z

Fig. 4. DG function in discriminatory contextual fear conditioning (CFC).

Fig. 4

a | Schematic of discriminative CFC. b | Illustration of the physiological DG and CA3 activation patterns evoked by overlapping PP-inputs encoding similar contexts. Young and mature GC show similar activity patterns in both contexts. Young- and recently-active GCs potently recruit feed-forward inhibition45,89 and may thus suppress firing of CA3 pyramidal cells with overlapping synaptic input-patterns between the two contexts. This could spare less overlapping CA3 ensembles forming context-unique representations. c | Activation pattern as in b in a mouse model where MF-plasticity onto CA3 feed-forward interneurons was disrupted genetically by knocking out the gene encoding adducin 2 (Add2)47. Releasing CA3 from MF-recruited feed-forward inhibition unmasks the activation of larger CA3 ensembles with more overlapping activity between the two contexts.