Extended Data Fig. 6. Comparison of arrestin coupled to different GPCRs.

a, Superposition of arrestin molecules in the complexes of β₁AR_6P–βarr1 (green) and rhodopsin–arrestin (pale brown). The different angle between the respective receptors and coupled arrestins is shown by the 20° difference in tilt of H3 (blue, H3 in rhodopsin; red, H3 in β₁AR). b, Superposition of β₁AR_6P and β₂AR (pink and purple cartoons, respectively) coupled to either βarr1 (magenta surface) or G_s (blue and purple surfaces), respectively. c, Superposition of β₁AR_6P (rainbow cartoon) and NTSR1 (grey cartoon) coupled to βarr1 (magenta) and βarr1 (grey), respectively. d, Alignment in c viewed from the membrane surface and the respective molecules of βarr shown in surface representation. e, Superposition of the active state of βarr1 (pale brown; PDB ID: 4JQI) not bound to receptor and βarr1 (green) coupled to β₁AR_6P. The phosphopeptides are shown as sticks: yellow carbon atoms, V₂Rpp in 4JQI; magenta carbon atoms, V₂R_6P in the β₁AR_6P–βarr1 complex.