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. Author manuscript; available in PMC: 2020 Jul 31.
Published in final edited form as: Nature. 2020 Jun 17;583(7818):862–866. doi: 10.1038/s41586-020-2419-1

Fig. 4. Differences between formoterol-bound β1AR coupled to either βarr1 or Nb80.

Fig. 4

a-c, Superposition of β1AR6P coupled to βarr1 (blue) and β1AR coupled to Nb80 (grey), with residues interacting with the ligand shown as sticks. Residues labelled in orange interact with formoterol but not isoprenaline. d, Structures of arrestin-biased ligands (formoterol, carvedilol) and a balanced agonist (isoprenaline). Regions in blue are identical to adrenaline, and the red region in carvedilol is the oxypropylene linker that is typical of β-adrenoceptor antagonists of the G-protein pathway.