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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Jan 11;138:302–325. doi: 10.1016/j.addr.2019.01.005

Figure 7. Magnetic drug targeting and magnetic fluid hyperthermia.

Figure 7

A. Schematic depiction of magnetic fluid hyperthermia mechanism of action. The upper image shows the specific accumulation of magnetic nanoparticles (MNP) in tumor tissue due to leaky vasculature (EPR). The lower image exemplifies that after the application of an alternating current (AC) magnetic field, the SPION which have accumulated in the tumor heat up and lead to tissue damage [218]. B-C. MR images of patients with recurrent GBM before treatment. D. Fusion of MRI and CT (3D-reconstruction) shows the thermometry catheter in green, magnetic fluid in blue and glioblastoma tumor mass in brown. E. Overall survival of 59 glioblastoma patients after diagnosis of first tumor recurrence and treatment with combination of magnetic fluid hyperthermia and radiotherapy [219].