. Author manuscript; available in PMC: 2020 Aug 1.

Published in final edited form as: Adv Drug Deliv Rev. 2019 Jan 11;138:302–325. doi: 10.1016/j.addr.2019.01.005

Table 3. Key studies applying SPION in diagnosis, therapy and theranostics.

Field of application	Application	Indication	Product	Phase	Ref
Diagnosis	Lymph node staging, detection of small metastatic lymph nodes	Prostate cnacer	Ferumoxtran	Phase II	[157]
Diagnosis	Magnetic nanoparticle-based biosensors (DMR -diagnostic magnetic resonance) for detection of biomarkers	Cancer, inflammation	Surface modified CLIO	Market	[205]

Therapy	Iron supplement for anemic patients	Chronic kidney disease	Ferumoxytol	Market	[209]
Therapy	Magnetic fluid hyperthermia	Recurrent glioblastoma multiforme	NanoTherm^®	Market	[220]

Theranostics	Companion diagnostics, evaluate accumulation and predict treatment efficacy of nanomedical cancer therapy	Cancer	Ferumoxytol	Pilot study	[236]
Theranostics	Tagging of dendritic cell, injected intranodally and employed for immune system stimulation	Melanoma	Ferumoxide	Phase I	[126]

CLIO - cross linked iron oxide