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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Acc Chem Res. 2019 May 23;52(6):1543–1554. doi: 10.1021/acs.accounts.9b00148

Figure 6. The cancer immunogram and Immunoscore.

Figure 6

a: The cancer immunogram is a scoring tool based on seven parameters related to cancer-immune system interactions. MHC: major histocompatibility complex; LDH: lactate dehydrogenase; CRP: C-reactive protein. Adapted with permission from ref. 20. Copyright 2016 The American Association for the Advancement of Science. b: The Immunoscore aims to analyze the location, type, density and function of T cells in tumors. In the most recent version, tumors are categorized in four types: absent (“cold” tumors), altered-immunosuppressed, altered-excluded and optimal (“hot” tumors). The latter have an increased likelihood to respond to immunotherapeutic interventions, such as checkpoint inhibition. CT-Lo: low T cells in the core of tumors. Hi-IM: high T cells in the invasive margin. CD3+ T cells are stained in brown and background tissue is stained in blue. Adapted with permission from ref. 76. Copyright 2019 Springer Nature.