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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Chem Soc Rev. 2019 Jan 2;48(1):351–381. doi: 10.1039/c8cs00473k

Figure 5. Multivalent bi-specific nanobioconjugate engager (mBiNE) enhanced tumor cell endocytosis by macrophages.

Figure 5

a: Schematic illustration of mBiNE mediated macrophage endocytosis of cancer cells and immune response. b: mBiNE specifically induced phagocytosis of HER2high SK-BR-3 cells by THP-1 macrophages, which did not work in HER2low MDA-MB-468 cells. mBiNE treatment via local administration inhibited the growth of HER2high EO771/E2 tumor (c) but not in the HER2neg EO771 tumors (d) in mice. e: mBiNE induced more effective infiltration of CD4+ and CD8+ T cells in the HER2high EO771/E2 tumors than that in the HER2neg EO771 model. Adapted from ref. 78, with permission from Springer Nature, copyright 2017.