Table 3. Change scores intraclass correlation coefficients and average scores according to the RAMRIS in early arthritis patients (n=30) from baseline until 12 months of follow-up by two readers.
| Median change (IQR) | Mean change (SD) | Median change (IQR) | Mean change (SD) | Median change (IQR; max) | Mean change (SD) | ICC change (95% CI) | SDC | Change >0, n(%) | Change >0.5, n (%) | Change >SDC, n (%) | |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| Reader 1 | Reader 1 | Reader 2 | Reader 2 | Average both readers | Average both readers | ||||||
| MTP | |||||||||||
|
| |||||||||||
| BME | 0 (-2-0) | -1.2 (2.9) | 0 (-1-0) | -1.4 (2.9) | 0 (-1-0;-9.5) | -1.3 (2.9) | 0.97 (0.94-0.99) | 1.0 | 20 (67) | 11 (37) | 11 (37) |
| Synovitis | -1 (-4-0) | -1.6 (2.3) | -1 (-3-0) | -1.4 (2.5) | -0.75 (-3-0;-7) | -1.5 (2.4) | 0.90 (0.90-0.98) | 1.0 | 22 (73) | 20 (67) | 20 (67) |
| Tenosynovitis | -1 (-3-0) | -1.5 (1.9) | 0 (-2-0) | -1.2 (1.9) | -0.25 (-2.5-0;-7) | -1.4 (1.8) | 0.96 (0.91-0.98) | 0.7 | 16 (53) | 14 (47) | 14 (47) |
| Erosions | 0 (0-0) | 0.3 (0.7) | 0 (0-1) | 0.4 (0.7) | 0 (0-0.5;2) | 0.4 (0.6) | 0.77 (0.52-0.89) | 0.6 | 11 (37) | 5 (17) | 5 (17) |
|
| |||||||||||
| MCP | |||||||||||
|
| |||||||||||
| BME | 0 (-2-0) | -0.9 (1.9) | 0 (-2-0) | -0.8 (1.9) | 0 (-1.5-0;-6.5) | -0.9 (1.8) | 0.94 (0.88-0.97) | 0.9 | 16 (53) | 13 (43) | 13 (43) |
| Synovitis | -2 (-3-0) | -1.3 (2.8) | -2 (-3-0) | -1.4 (2.7) | -1.5 (-3-0.5;-6.5) | -1.4 (2.7) | 0.97 (0.93-0.98) | 1.0 | 26 (87) | 25 (83) | 25 (83) |
| Tenosynovitis | 0 (-3-0) | -1.4 (2.7) | 0 (-2-0) | -1.3 (2.6) | 0 (-2.5-0;-10) | -1.3 (2.6) | 0.97 (0.94-0.99) | 0.9 | 15 (50) | 14 (47) | 14 (47) |
| Erosions | 0 (0-1) | 0.4 (0.7) | 0 (0-1) | 0.4 (0.6) | 0 (0-1;2) | 0.4 (0.6) | 0.94 (0.87-0.97) | 0.3 | 11 (37) | 9 (30) | 11 (37) |
|
| |||||||||||
| Wrist | |||||||||||
|
| |||||||||||
| BME | -1 (-3-0) | -2.8 (5.4) | -1 (-5-0) | -2.9 (4.8) | - 1 (-4-0;-19) | -2.8 (5.0) | 0.98 (0.96-0.99) | 1.5 | 25 (83) | 20 (67) | 14 (47) |
| Synovitis | -1 (-4-0) | -1.6 (2.8) | -2 (-4-0) | -2.3 (2.8) | -1.5 (-4-0;-7.5) | -2.8 (5.0) | 0.96 (0.81-0.98) | 0.9 | 24 (80) | 20 (67) | 20 (67) |
| Tenosynovitis | -2 (-4-0) | -2.6 (3.3) | -2 (-5-0) | -2.6 (3.1) | -1.5 (-4.5-0;-10.5) | -2.6 (3.2) | 0.98 (0.96-0.99) | 0.9 | 23 (77) | 19 (63) | 19 (63) |
| Erosions | 0 (0-1) | 1.0 (2.3) | 0 (0-1) | 0.7 (1.6) | 0 (0-1;8) | 0.9 (1.9) | 0.91 (0.81-0.96) | 1.1 | 18 (60) | 9 (30) | 5 (17) |
IQR: interquartile range; SD: standard deviation; ICC: intraclass correlation coefficient; CI: confidence interval; SDC: smallest detectable change; n: number; MTP: metatarsophalangeal; MCP: metacarpophalangeal; BME: bone marrow edema. The change scores of individual readers (reader 1 and reader 2) are depicted, in addition to the average change over time of both readers (‘median change’ and ‘mean change’). Change ICCs are based on a mean-rating, absolute agreement, two-way mixed effects model. ‘Change, n’ is defined as the numbers of patients with change of more than an average of both readers of >0 or >0.5.‘Change >SDC, n’ represents the number of patients with change after using the SDC as a cut-off.