. Author manuscript; available in PMC: 2020 Aug 18.

Published in final edited form as: Cancer Chemother Pharmacol. 2016 Oct 13;78(5):1051–1058. doi: 10.1007/s00280-016-3166-8

Table 2. Population pharmacokinetics of plasma Dnr and DOL in AML.

Parameter	Population mean	rse (%)	Inter-individual variability (CV %)	rse (%)
DNR
Clearance (L/hr)	269.8	10	84	18
Volume (L)	15.0	21	143	21
K12 (1/hr)	22.4	16	69	43
K21(1/hr)	0.6	9	72	19
DOL
Clearance (L/hr)	23.6	11	64	32
Volume (L)	7.6	16	65	42
K12 (1/hr)	32.0	18	73	39
K21(1/hr)	0.4	10	68	27
Residual error	Relative error (CV %)
DNR	47	6
DOL	34	6

rse relative standard error