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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Nat Rev Cancer. 2020 Feb 5;20(4):218–232. doi: 10.1038/s41568-019-0235-4

Figure 3. Hallmarks of intratumoral tumor-reactive CD8+ T cells.

Figure 3

This schematic depicts protein markers and functional properties that are enriched in tumor-reactive CD8+ T cells (i.e. T cells that express a tumor-reactive T cell receptor (TCR), irrespective of their functional capacity) relative to bystander CD8+ T cells at the tumor site. Note that none of these characteristics by themselves identify tumor-reactive CD8+ T cells with absolute precision and that for some of these markers (4-1BB, GITR, and CXC-chemokine ligand 13 (CXCL13)), the evidence is less well established. LAG3, lymphocyte activation gene 3 protein; PD1, programmed cell death protein 1; TIM3, T-cell immunoglobulin mucin receptor 3.