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. Author manuscript; available in PMC: 2020 Nov 27.
Published in final edited form as: Cell. 2019 Nov 27;179(6):1264–1275.e13. doi: 10.1016/j.cell.2019.11.001

Figure 1. TLR7 and TLR8 Are Functional TLRs in BLaER1 Monocytes.

Figure 1

(A and B) BLaER1 monocytes of indicated genotypes were stimulated with (A) TL8-506, R848, and LPS or were (B) unstimulated or stimulated with pR and RNA40S. After 14 h, IL-6 release was measured. (C) TLR8 expression in BLaER1 cells of indicated genotypes. (D) Control and TLR8-deficient BLaER1 monocytes were stimulated with increasing amounts of RNA40S. After 14 h, IL-6 was measured. Data are depicted as mean + SEM of three independent experiments (A, B, and D) or one of three representative blots (C). Statistics indicate significance by two-way ANOVA: ***p ≤ 0.001; **p ≤ 0.01; *p ≤ 0.05; ns, not significant. See also Figure S1.