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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Nat Genet. 2019 Jul 15;51(8):1272–1282. doi: 10.1038/s41588-019-0462-3

Figure 2. The impact of chromosomal rearrangements on gene expression.

Figure 2

a, Chromosomal rearrangements generally have a modest effect on gene expression: MA-plot of genome-wide differential gene expression between wild-type and balancer haplotypes. 512 differentially expressed (DE) genes indicated in orange (two-sided Wald test, 5% FDR). b, Change in gene expression (log2 fold change) for testable genes fully duplicated (n=21) or disrupted by balancer breakpoints (n=9). Points, individual genes; center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; dashed lines, expectation for duplications (two-fold increase or decrease).