Table 1.
Granulocyte associated genes within the Inflammasome (HB3, left) and the Innate immunity/PRR/C’ (HB8, right) modules that are over-expressed in the blood of TB patient cohorts from London, South Africa and Leicester, compared to healthy controls (58 out of 87, and 53 out of 92 Granulocyte associated genes, respectively).
| (HB3) Inflammasome*** | |||
|
| |||
| ABCA13 | DMXL2 | KIF1B | NTNG2 |
| AIF1 | EVI2A | LCN2 | OSM |
| APOBR | FAS | LILRB5 | PLA2G4A |
| ASPRV1 | FCGR3B | LPCAT2 | PPP1R3D |
| ATP8B4 | FGL2 | LTF | PRTN3 |
| CAMP | GAS7 | LY96 | RNASEL |
| CASP4 | GPR141 | MARCKS | S100A6 |
| CCR1 | GSN | MCEMP1 | SELL |
| CD177 | HIST1H2BC | MCTP1 | SIGLEC9 |
| CD300A | HP | MEFV | SOCS3 |
| CKAP4 | IL18RAP | MILR1 | TFEC |
| CLEC4A | IL1B | MMP8 | TLR5 |
| CLEC4D | IRAK3 | NAIP | VCAN |
| CLEC4E | KCNJ2 | NCF1 | |
| CLEC5A | KCTD12 | NOD2 | |
|
| |||
| (HB8) Innate immunity/PRR/C'*** | |||
|
| |||
| ACSL1 | FUT7 | MXD1 | REPS2 |
| ALOX5AP | GAB2 | MYBPC3 | RNF19B |
| ANXA3 | GLIPR2 | NCF2 | RRAGD |
| AQP9 | HCAR2 | P2RX1 | S100A11 |
| ARL11 | HRH2 | P2RY13 | S100A8 |
| BCL6 | IFNGR2 | PADI4 | S100A9 |
| BMX | IGSF6 | PGLYRP1 | SIPA1L2 |
| BST1 | ITGAM | PLBD1 | SLC22A4 |
| C1RL | JAML | PPP1R3B | STEAP4 |
| C5AR1 | LITAF | PTPRJ | TIMP2 |
| CHST15 | LRG1 | PYGL | TLR2 |
| CRISPLD2 | LYN | RAB31 | TLR6 |
| ENTPD1 | MMP9 | RALB | |
| FOSL2 | MNDA | RBM47 | |