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. 2020 Feb 29;1(1):3–25. doi: 10.37349/etat.2020.00002

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© The Author(s) 2020.

This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Figure 2. — An overview of mRNA translation initiation. The Figure shows some of the key steps in initiation of translation. The process initiates with the joining of the eIF4F complex (eIF4A, eIF4E and eIF4G), the tertiary complex, the 40S ribosome subunit and accessory eIFs. Interactions between eIF4G and PABP lead to closed-loop formation/mRNA circularization. The subsequent steps of scanning, initiation codon recognition and large ribosome subunit joining are accompanied by eIF2-GTP hydrolysis, release of eIF2-GDP and other eIFs. Note figure is illustrational and does not show all intermediate steps. See text for further details