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. Author manuscript; available in PMC: 2020 Sep 15.
Published in final edited form as: Chem Rev. 2016 May 17;116(13):7673–97. doi: 10.1021/acs.chemrev.5b00664

Figure 1.

Figure 1

(a) Molecular jump mechanism. (b) Schematic figure with a protein interface and the three types of sites, respectively hydrophobic, H-bond donor, and H-bond acceptor, together with a pictorial representation of the types of perturbation they induce on water dynamics (excluded volume and H-bond strength factors). This figure is reproduced with permission from ref 36. Copyright 2013 Royal Society of Chemistry.