Table I. Characteristics of the patients with mastocytosis analyzed on the chip (mechanisms for development of allergies).
| Mastocytosis: Variants and subvariants | n (%) | F/M | Age (y), median (min-max) | Tryptase (ng/mL) median, (min-max) | WBC (cells/μL) median, (min-max) | Eosinophils (cells/μL) median, (min-max) | Platelets (cells/μL), Median (min-max) | History of allergies, n (%) | Mediator symptoms, n (%) |
|---|---|---|---|---|---|---|---|---|---|
| Nonadvanced mastocytosis | |||||||||
| CM | 4 (9.5) | 3/1 | 37 (33-45) | 13.05 (6-17) | 7,210 (5,720-10,000) | 164.4 (57.6-259.8) | 266,500 (158,000-378,000) | 2 (50.0) | 2 (50.0) |
| MIS | 2 (4.8) | 2/0 | 33 (31-35) | 13.5 (14-14) | 7,800 (7,800-7,800) | 0 (0-0) | 305,000 (305,000-305,000) | 0 (0.0) | 1 (50.0) |
| ISM | 23 (54.8) | 14/9 | 45 (26-73) | 46.5 (15-938) | 6,620 (3,750-10,880) | 102.2 (0-488) | 265,000 (204,000-341,000) | 6 (26.1) | 14 (60.9) |
| SSM | 5 (11.9) | 4/1 | 48 (35-55) | 352.5 (175-1,090) | 4,860 (3,820-6,800) | 0 (0-0) | 212,000 (193,000-280,000) | 1 (20.0) | 4 (80.0) |
| Advanced mastocytosis | |||||||||
| ASM | 3 (7.1) | 0/3 | 59 (21-72) | 285 (54-1,617) | 5,030 (4,370-6,760) | 349.6 (100.6-1,487.2) | 115,000 (25,000-269,000) | 0 (0.0) | 2 (66.7) |
| SM-AHN | 5 (11.9) | 2/3 | 53 (47-72) | 379 (78-615) | 17,600 (2,950-35,490) | 797.5 (59-2,515.5) | 93,500 (54,000-287,000) | 0 (0.0) | 3 (60.0) |
| All patients | 42 | 25/17 | 45.5 (21-73) | 53.6 (6-1,617) | 6,535 (2,950-35,490) | 100 (0-2,515.5) | 253,500 (274-378,000) | 9 (21.0) | 26 (65.0) |
F, Female; M, male; WBC, white blood cell.
Mediator symptoms include flush, vascular instability, headache, bone pain, and diarrhea.