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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Nat Cancer. 2020 Sep 21;1(10):976–989. doi: 10.1038/s43018-020-00112-5

Figure 2. Analysis of mitochondrial DNA (mtDNA) mutations detected in 26 colorectal adenocarcinomas compared with normal aged crypts.

Figure 2

a-c: Location, type and consequences of mtDNA mutations detected in colorectal adenocarcinomas in this study (n=41 mutations). d-g: Comparison of the location (d), types (e), and functional consequences (f) of mtDNA mutations in previously published normal crypts (n=129 mutations) and adenocarcinomas11,13,21,23 (n=182 mutations). There was a significant difference in the location of the mtDNA mutations in adenocarcinomas compared with normal aged crypts (p=0.0123, Chi-squared analysis (d)), but no significant differences were detected in the types of mutations (p=0.2264, Chi-squared analysis, (e)) or the predicted functional consequences (p=0.1504, Chi-squared analysis (f)). (g) Comparison of MutPred pathogenicity scores for missense mutations in protein encoding genes in normal aging crypts (n=52 mutations) and adenocarcinomas (n=80 mutations) two-tailed, Mann Whitney U Test, p=0.8138, median ±95% confidence intervals are shown. * p<0.05

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