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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Hepatol. 2020 Jun 10;73(5):1219–1230. doi: 10.1016/j.jhep.2020.06.004

Fig. 5. Bipotent progenitor cell in the normal human liver revealed by scRNA-seq.

Fig. 5

ScRNA-seq of human liver identified an EPCAM+TROP2inter CK19low progenitor cell which has the potential to differentiate into cholangiocytes or hepatocytes (human data). Upon liver damage, progenitor cells upregulate WNT-and YAP-target genes promoting liver regeneration (mouse data). ScRNA-seq, single-cell RNA-sequencing.