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. Author manuscript; available in PMC: 2021 Mar 4.
Published in final edited form as: Science. 2020 Sep 4;369(6508):1220–1227. doi: 10.1126/science.aba4904

Fig. 3. Interactions of peripheral subunits of eIF3.

Fig. 3

(A) eIF3g-RNA binding motif viewed from solvent side to highlight its interaction with rRNA in helix 16 and ribosomal proteins uS3 and eS10. (B) Binding interface between eIF3g and the ribosomal protein uS3 at the mRNA entry channel. H, His; I, Ile; L, Leu; Y, Tyr. (C) eIF3j binds to ribosomal proteins eS30 and uS12 near the A site. The C-terminal tail of eIF3j (eIF3j-CTT) interacts with ribosomal rRNA in helix 34. eIF3j-NTT is positioned next to the GTPase binding region of the 40S. (D) Superposition of eIF3j with the structure of ABCE1 (PDB: 5LL6) bound to the 40S subunit (post splitting) (29). (E and F) eIF3j-NTT extends toward the GTPase binding region of the 40S, where the nucleotide binding domain 1 (NBD1) of ABCE1 binds.