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. Author manuscript; available in PMC: 2022 Oct 4.
Published in final edited form as: Biosens Bioelectron. 2019 Feb 1;131:24–29. doi: 10.1016/j.bios.2019.01.052

Scheme 1.

Scheme 1

Modification of Au electrode (upper row) using carboxybetaine aryldiazonium derivative (CB) and lectin (SNA-I). In the first step, carboxybetaine-bearing SAM layer was formed using cyclic voltammetry, and subsequently served for the covalent immobilization of a lectin. Lower row shows MP@silica@Au composite spontaneously modified with CB-derivative and subsequently with an antibody (Ab, anti-fPSA, chemically treated). After enrichment of fPSA from human sample using MP@silica@Au/CB/Ab by a permanent magnet, a sandwich was prepared and the signal was evaluated electrochemically.