Figure 4. CN profiling facilitates earlier treatment and reduced monitoring.

a. Provides a schematic overview of surveillance guidelines based on the CN model risk classes. It is important to note that these guidelines would apply at each endoscopy, and that they use information from the previous endoscopy to determine the treatment or surveillance. b. Uses this schematic to characterize the discovery cohort patients after their second endoscopy (many years prior to dysplastic transformation). The blue bar at the top indicates the number of non-progressor patients who would have reduced treatment needs over time, while the red bar at the bottom shows those progressor patients who would have had earlier intervention. The bars in the middle two groups would be the same as current guidelines. c-e. Individual patients with each sample plotted at the time of endoscopy. Samples are colored based on their risk class. Relevant clinical information is included above each endoscopy plot including the length of the BE segment and patient age at diagnosis. The recommendations for each patient based on the 2015 BE management guidelines³³ are shown on each patient tile. Below the patients are the overall follow-up recommendations for the current guidelines and the CN model.