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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Nat Microbiol. 2020 Oct 26;5(12):1588–1597. doi: 10.1038/s41564-020-00801-y

Extended Data Figure 4. NLRC4 does not affect protection against lethal rechallenge.

Extended Data Figure 4

Wild-type and nlrc4-/- mice were challenged with either sterile PBS (naïve) or 1-1.15x104 CFU S. Typhimurium M525P and allowed to clear the primary infection for 90-106 days. They were then re-challenged orally with 1.37-7.2x107 CFU S. Typhimurium SL1344 to establish a lethal infection and inspected twice daily. They were euthanized upon detection of adverse signs and a humane end point curve was constructed for a, naïve mice and b, mice “immunised” with Salmonella. Data has been pooled from 2 independent experiments. Statistical significance was calculated by a two-sided log-rank test.