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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Nat Metab. 2020 Nov 9;2(11):1350–1367. doi: 10.1038/s42255-020-00306-2

Extended Data Fig. 8. c-Rel signaling in hepatocyte and macrophages differentially regulate liver regeneration via regulation of cell cycle genes and mitogenic factors.

Extended Data Fig. 8

(a) Histological assessment and representative images of PCNA positive hepatocytes in 48h partial hepatectomy injured Rel flfl, RelΔAlb (p=0.0003) and Rel ΔLysM (p=0.0096) mice. Scale bar is 100 microns. (b) Graph shows average liver/body weight ratio 48h post partial hepatectomy in Rel flfl, RelΔAlb (p=0.0318) and Rel ΔLysM (p=0.0178) mice. (c) Heat map showing relative hepatic mRNA expression of cell cycle genes; Ccna1, Ccnd1, Ccne1, Cdk2, Cdk4 and mitogenic proteins; Hgf and Egf at 48h post partial hepatectomy in Rel flfl, RelΔAlb and Rel ΔLysM mice. Data are mean ± s.e.m. in n=5 mice/group. P values were calculated using one-way ANOVA with Tukey post-hoc t-test (* P <0.05 and ** P <0.01).