Table 5. ‘Concurrent’ model to assess the longitudinal relationship between incident anxiety and agitation at the same follow-up time points within ‘at risk’ individuals.
Values are odds ratios (to 1 decimal place) for baseline agitation measured in the ‘at risk’ sample (N=272) using multivariate random effects models, with 95% confidence intervals (CI) before (OR) and after adjustment for other incident NPI-rated covariates (AOR-1) and demographic factors (baseline age, MMSE at each timepoint, sex, years of education; AOR-2). The variables that had interaction terms with anxiety worsened the fit of the unadjusted model according to the LRT so were not included in this or subsequent models. Statistically significant results (p<0.05) are highlighted in bold and indicated by (**), otherwise results were not significant. The composite subscale of agitation was defined as having at least 3 of NPI-rated agitation, disinhibition, irritability and aberrant motor behavior being present.
| Model variables | Incident anxiety | Time (months) | Group (AD vs MCI/CN) | Incident NPI-A (delusions) | Incident NPI-B (hallucinations) | Incident NPI-D (depression/dysphoria) | Incident NPI-F (elation/euphoria) | Incident NPI-G (apathy/indifference) | Incident NPI-H (disinhibition) | Incident NPI-I (irritability/lability) | Incident NPI-J (motor disturbance) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Agitation/aggression (NPI-Q) | OR (95% CI) | 2.7(1.8-4.2) ** | 1.1(1.0-1.1) ** | 1.9(1.1-3.3) ** | - | - | - | - | - | - | - | - |
| AOR-1 (95% CI) | 1.6(1.0-2.5) ** | 1.0(1.0-1.1) ** | 1.5(0.9-2.5) | 1.1(0.6-2.3) | 0.7(0.3-2.0) | 1.6(1.1-2.5) ** | 0.5(0.2-1.3) | 1.8(1.2-2.8) ** | 3.9(2.3-6.6) ** | 3.3(2.1-5.0) ** | 2.0(1.1-3.5) ** | |
| AOR-2 (95% CI) | 1.6(1.0-2.4) ** | 1.0(1.0-1.1) ** | 1.4(0.8-2.4) | 1.1(0.5-2.1) | 0.7(0.2-2.0) | 1.6(1.0-2.4) ** | 0.5(0.2-1.3) | 1.8(1.2-2.8) ** | 3.9(2.3-6.6) ** | 3.4(2.2-5.3) ** | 2.0(1.1-3.5) ** | |
| Agitation (composite) | OR (95% CI) | 6.2(3.1-12.2) ** | 1.0(1.0-1.1) ** | 3.0(1.3-7.0) ** | - | - | - | - | - | - | - | - |
| AOR (95% CI) | 4.0(2.0-7.9) ** | 1.0(1.0-1.1) | 2.4(1.1-5.4) ** | 2.5(1.1-6.1) ** | 1.0(0.3-3.6) | 2.1(1.1-3.9) ** | 2.7(0.8-9.2) | 3.3(1.7-6.2) ** | - | - | - | |
| AOR-2 (95% CI) | 3.8(2.0-7.6) ** | 1.0(1.0-1.1) | 1.9(0.8-4.7) | 2.5(1.0-6.2) ** | 0.7(0.2-2.9) | 2.3(1.2-4.4) ** | 2.5(0.7-8.9) | 3.0(1.6-5.8) ** | - | - | - |