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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Nat Phys. 2020 Aug 10;16(12):1232–1237. doi: 10.1038/s41567-020-0978-6

Figure 4. Scaling laws allow for cancer patient classification into prognostic groups.

Figure 4

Patient tumours were classified as hyperactive (TLA > aV5/4; DSL > 0) or hypoactive (TLA < αV5/4; DSL < 0) using the metabolic scaling law as a reference. Survival differences between groups were compared using Kaplan-Meier analysis and the c-index. Shown are Kaplan-Meier survival curves and the best c-index values obtained for: (a) Gliomas (p =0.001, c-index = 0.832, α = -0.24867). (b) Head and Neck cancer (p =0.05, c-index = 1.0, a = -0.0041776). (c) Stage III and IV resectable lung cancer patients (p=0.09, c-index = 0.742, α = -0.40334). (d) Breast cancer (p =0.019, c-index = 0.849, α =-0.65034).