Table 3. Potential interaction partners of FAHD proteins, as listed in the BioPlex (Huttlin et al., 2015) network of different versions. Highlighted in gray are proteins that are listed in the newest versions 2 and 3 of the network. Other proteins were listed in early versions of the network but removed in the latest stable version 3. Localization and description of the proteins was gathered from the Human Protein Atlas (Uhlen et al., 2005; Fagerberg et al., 2014; Uhlen et al., 2010) and the UniProt (Wasmuth and Lima, 2017) database.

Enzyme	Interaction	BioPlex	Localization (Human Protein Atlas, UniProt)	Description
	ARL2	3.0	Nucleoplasm, Nucleoli, Golgi apparatus, Focal adhesion sites, Cytosol	ADP ribosylation factor like GTPase 2
	PTRHD1	3.0	Nucleoplasm	Peptldyl-tRNA hydrolase domain containing 1
	CPT2	3.0, 2.0, 1.0	Nucleoplasm, Nucleoli, Mitochondria	Carnitine palmitoyltransferase 2
	DHRS4	3.0	Vesicles, Nuclear membrane	Dehydrogenase/reductase 4
	DHTKD1	2.0, 1.0	Mitochondria	Dehydrogenase El and transketolase domain containing 1
	FSD1	2.0, 1.0	Nucleus	Flbronectin type III and SPRY domain containing 1
FAHD1	INHA	3.0	Vesicles	Inhibin alpha subunit
	CLUH	3.0, 2.0, 1.0	Vesicles, Nuclear bodies	Clustered mitochondria homolog
	MTERFD1	3.0	Nucleoplasm, Mitochondria	Mitochondrial transcription termination factor 3
	NDUFS6	3.0, 2.0	Mitochondria	NADH:ublquinone oxldoreductase subunit S6
	OR10H3	2.0, 1.0	Cell membrane	Olfactory receptor family 10 subfamily H member 3
	PNPT1	3.0, 2.0, 1.0	Mitochondria	Polyribonucleotide nucleotidyltransferase 1
	UBR3	3.0, 2.0, 1.0	Nucleoplasm, Nucleoli	Ubiquitln protein llgase E3 component n-recognin 3 (putative)
	BOLA3	3.0, 2.0, 1.0	Nuclear bodies, Mitochondria, Cytosol	BolA family member 3
	DBT	3.0, 2.0, 1.0	Mitochondria	Dlhydrolipoamide branched chain transacylase E2
	FAHD2B	3.0, 2.0	unreported	Fumarylacetoacetate hydrolase domain containing 2B
	FCER1A	3.0	Cell membrane	Fc fragment of IgE receptor la
	FCGR2A	2.0	Plasma membrane, Golgi apparatus	Fc fragment of IgG receptor lia
FAHD2A	LCN8	3.0	Secreted	Lipocalin 8
	OMP	3.0	Cytoplasm	Olfactory marker protein
	SETX	3.0	Nucleoplasm, Cytokinetic bridge	Senataxin
	SOX2	3.0, 2.0, 1.0	Nucleoplasm	SRY-box2
	TAS2R41	2.0	Cell membrane	Taste 2 receptor member 41
	ZNF287	3.0	Golgi apparatus	Zinc finger protein 287
	BOLA3	3.0	Nuclear bodies, Mitochondria, Cytosol	BolA family member 3
	DBT	3.0	Mitochondria	Dlhydrolipoamide branched chain transacylase E2
FAHD2B	FAHD2A	3.0	unreported	Fumarylacetoacetate hydrolase domain containing 2A
	FCGR2A	1.0	Plasma membrane, Golgi apparatus	Fc fragment of IgG receptor lia
	HSPD1	3.0, 2.0	Mitochondria	Heat shock protein family D (Hsp60) member 1