Table 1. Amino acid sequence of the most important members of the gastrin/CCK family.
Natural ligand | Amino acid sequence* |
---|---|
Gastrin-17 (gastrin-I) | Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 |
Gastrin-13 (minigastrin) | Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 |
Cholecystokinin-8 (CCK-8) | Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 |
Cholecystokinin-4 (CCK-4) | Trp-Met-Asp-Phe-NH2 |
bold letters = amino acids known to be involved in receptor binding